Clemson vs Notre Dame College Football Picks and Predictions Today on this Week 10 football game.

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The Notre Dame Fighting Irish will host the Clemson Tigers in this big ACC Saturday Night game kicking off at 7:30pm et. The current college football odds have Clemson as -6 favorites and the over/under at 50 total points. Clemson is 8-3 against the spread their last 11 games played in November. and the total has gone over in 11 of the Tigers last 15 games played in week 10. Notre Dame is 6-0 straight up in their last 6 games this season and the Fighting Irish are 2-4 against the spread in their last 6 games.